Špela Janež

1. GUZELJ, Samo, JANEŽ, Špela, JAKOPIN, Žiga. Discovery of desmuramylpeptide NOD2 agonists with single-digit nanomolar potency. ACS Medicinal Chemistry Letters. 2022, vol. 13, iss. 8, str. 1270-1277, ilustr. ISSN 1948-5875. https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.2c00121, Repozitorij Univerze v Ljubljani – RUL, DOI: 10.1021/acsmedchemlett.2c00121. [COBISS.SI-ID 117643267]
projekt: P1−0208; financer: ARRS
projekt: P1−0420; financer: ARRS
projekt: J3−9256; financer: ARRS

2. JANEŽ, Špela. Farmakokinetična in farmakodinamična optimizacija dezmuramilpeptidnih agonistov receptorja prirojene imunosti NOD2 = Pharmacokinetic and pharmacodynamic optimisation of desmuramylpeptide agonists of innate immune receptor NOD2. V: PLEVNIK, Miha (ur.), et al. 52. Krkine nagrade = 52nd Krka Prizes : zbornik povzetkov = book of abstracts : 32. simpozij = 32nd symposium : [Novo mesto, 21. oktober 2022]. Novo mesto: Krka, [2022]. Str. 77. [COBISS.SI-ID 126963715]

3. JANEŽ, Špela. Farmakokinetična in farmakodinamična optimizacija dezmuramilpeptidnih agonistov receptorja prirojene imunosti NOD2 = Pharmacokinetic and pharmacodynamic optimization of desmuramylpeptide agonists of the innate immune receptor NOD2 : [delo za Prešernovo nagrado]. Ljubljana: [Š. Bizjak], 2022. VI, 78 f., ilustr., tabele. [COBISS.SI-ID 174542339]

4. JANEŽ, Špela. Farmakokinetična in farmakodinamična optimizacija dezmuramilpeptidnih agonistov receptorja prirojene imunosti NOD2 = Pharmacokinetic and pharmacodynamic optimization of desmuramylpeptide agonists of the innate immune receptor NOD2 : enoviti magistrski študij farmacija. Ljubljana: [Š. Bizjak], 2022. X, 77 str., ilustr. [COBISS.SI-ID 111577603]

5. GUZELJ, Samo, ŠIŠIĆ, Marcela, JANEŽ, Špela, FRKANEC, Leo, FRKANEC, Ruža, JAKOPIN, Žiga. Lipidation of NOD2 agonists with adamantane and stearoyl moieties differentially regulates their In vivo adjuvant activity. Pharmaceutics. [Online ed.]. 2022, vol. 14, iss. 12, art. 2755, 9 str., ilustr. ISSN 1999-4923. https://www.mdpi.com/1999-4923/14/12/2755, Repozitorij Univerze v Ljubljani – RUL, DOI: 10.3390/pharmaceutics14122755. [COBISS.SI-ID 133033219]
projekt: P1-0208; financer: ARRS
projekt: P1-0420; financer: ARRS
projekt: J3-2517; financer: ARRS
projekt: J3-9256; financer: ARRS
projekt: IP-2018-01-6910; financer: Croatian Science Foundation

6. PARADISO, Emiliano, JANEŽ, Špela, GUZELJ, Samo, JAKOPIN, Žiga. Development of chimeric innate immune agonists as vaccine adjuvants. V: KRAJNC, Alen (ur.), GOBEC, Martina (ur.). Brunching with soft- and research skills at UL FFA: unlocking your full potential : 1st UL FFA Graduate Student Research Symposium : book of abstracts : University of Ljubljana, Faculty of Pharmacy, April 2024. Online ed. Ljubljana: Faculty of Pharmacy, 2024. Str. 36, ilustr. ISBN 978-961-6378-97-0. https://www.ffa.uni-lj.si/docs/default-source/e-knjige/brunching-with-soft-and-research-skills-at-ul-ffa.pdf?sfvrsn=2. [COBISS.SI-ID 198157059]

7. JANEŽ, Špela, GUZELJ, Samo, KOCBEK, Petra, DE VLIEGER, Eveline A., SLÜTTER, Bram, JAKOPIN, Žiga. Distinctive immune signatures driven by structural alterations in desmuramylpeptide NOD2 agonists. Journal of medicinal chemistry. [Online ed.]. 2024, vol. 67, iss. 19, str. 17585-17607, ilustr. ISSN 1520-4804. https://pubs.acs.org/doi/10.1021/acs.jmedchem.4c01577, Repozitorij Univerze v Ljubljani – RUL, DOI: 10.1021/acs.jmedchem.4c01577. [COBISS.SI-ID 209432835]
projekt: This research was funded by the Slovenian Research Agency (Grants P1-0420, J3-2517, J3-4496 and Young Researcher’s programme, 56838 (Š.J.)).

8. JANEŽ, Špela, GUZELJ, Samo, JAKOPIN, Žiga. Linker chemistry and connectivity fine-tune the immune response and kinetic solubility of conjugated NOD2/TLR7 agonists. Bioconjugate chemistry. [Online ed.]. 2024, vol. 35, iss. 11, str. 1723-1731, ilustr. ISSN 1520-4812. https://pubs.acs.org/doi/10.1021/acs.bioconjchem.4c00321, https://pubs.acs.org/doi/epdf/10.1021/acs.bioconjchem.4c00321?ref=article_openPDF, Repozitorij Univerze v Ljubljani – RUL, DOI: 10.1021/acs.bioconjchem.4c00321. [COBISS.SI-ID 211169539]
projekt: This research was funded by the Slovenian Research Agency(Grants P1-0420, J3-2517, J3-4496, and Young Researcher’sprogram, 56838.

9. JANEŽ, Špela, HAMERŠAK, Nuša, JAKOPIN, Žiga. Optimization of NOD2 agonistic activity through acylation of desmuramylpeptides. V: KRAJNC, Alen (ur.), GOBEC, Martina (ur.). Brunching with soft- and research skills at UL FFA: unlocking your full potential : 1st UL FFA Graduate Student Research Symposium : book of abstracts : University of Ljubljana, Faculty of Pharmacy, April 2024. Online ed. Ljubljana: Faculty of Pharmacy, 2024. Str. 30, ilustr. ISBN 978-961-6378-97-0. https://www.ffa.uni-lj.si/docs/default-source/e-knjige/brunching-with-soft-and-research-skills-at-ul-ffa.pdf?sfvrsn=2. [COBISS.SI-ID 198130179]

10. BELE, Klemen. Proučevanje vpliva zamenjave glicina z aromatskimi in heteroaromatskimi aminokislinami na agonistično aktivnost dezmuramilpeptidov na nukleotid-vezočo oligomerizacijsko domeno vsebujoč protein 2 = Investigating the impact of glycine replacement with aromatic and heteroaromatic amino acids on nucleotide-binding oligomerization domain protein 2 agonistic activity of desmuramylpeptides : enoviti magistrski študij farmacija. Ljubljana: [K. Bele], 2024. VII, 58 f., ilustr. [COBISS.SI-ID 198886915]

11. JANEŽ, Špela, DE VLIEGER, Eveline A., SLÜTTER, Bram, JAKOPIN, Žiga. Tailoring NOD2 agonists : minor structural alterations uncover diverse immune signatures. V: PINTAR, Albin (ur.). Slovenski kemijski dnevi 2024 : zbornik povzetkov = book of abstracts : 30 let = 30 years : 18.-20. september 2024, Bernardin, Portorož. Elektronska izd. Ljubljana: Slovensko kemijsko društvo, 2024. Str. 180. ISBN 978-961-95922-3-6. https://skd2024.chem-soc.si/wp-content/uploads/2024/08/SKD-2024-Zbornik-povzetkov_compressed.pdf. [COBISS.SI-ID 208694531]

12. JAKOPIN, Žiga, GUZELJ, Samo, JANEŽ, Špela. Conjugated TLR7 and RIG-I agonists : international application number: PCT/EP2024/073534 : international publication number (43) International Publication Date WO 2025/040743 A1. [Geneva]: World Intellectual Property Organization, International Bureau, 2025. 1 spletni vir (1 datoteka PDF (48 str., 4 f. pril.)), ilustr. https://patentimages.storage.googleapis.com/ab/70/d9/9f692f5415c2b0/WO2025040743A1.pdf. [COBISS.SI-ID 235938307]

13. JAKOPIN, Žiga, GUZELJ, Samo, JANEŽ, Špela. Conjugated TLR7 and TLR4 agonists = Agonistes conjugués de TLR7 et de TLR4 : international application number: PCT/EP2024/080788 : international publication number (43) International Publication Date WO 2025/093657 A1. [Geneva]: World Intellectual Property Organization, International Bureau, 2025. 1 spletni vir (1 datoteka PDF (67 str., 4 f. pril.)), ilustr. https://patentscope.wipo.int/search/en/WO2025093657. [COBISS.SI-ID 235939843]

14. CAR, Željka, KOVAČEVIĆ, Monika, PETROVIĆ PEROKOVIĆ, Vesna, ČIŽMEŠIJA, Karla, RIBIĆ, Rosana, JANEŽ, Špela, JAKOPIN, Žiga, BARIŠIĆ, Lidija. Ferrocene-containing desmuramylpeptides adopt a flexible conformation and exhibit NOD2 agonistic activity. Organometallics. 2025, vol. 44, no. 20, str. 2440–2456, ilustr. ISSN 1520-6041. https://pubs.acs.org/doi/10.1021/acs.organomet.5c00312, Repozitorij Univerze v Ljubljani – RUL, DOI: 10.1021/acs.organomet.5c00312. [COBISS.SI-ID 253252867]
projekt: This work was supported by the Croatian Science Foundation under the project number IP-2020-02-9162 and Slovenian Research and Innovation Agency (P1-0420, J3-4496).

15. PARADISO, Emiliano, JANEŽ, Špela, JAKOPIN, Žiga. Linker chemistry modulates solubility and immune response in conjugated NOD2/TLR4 dual agonists. V: JAKOPIN, Žiga (ur.), TOMAŠIČ, Tihomir (ur.). Crossing the Boundaries of Medicinal Chemistry : book of abstracts : Ljubljana, 25th September 2025. Ljubljana: Faculty of Pharmacy, 2025. Str. 29. ISBN 978-961-7231-07-6. [COBISS.SI-ID 252264451]

16. PARADISO, Emiliano, JANEŽ, Špela, JAKOPIN, Žiga. Modulating receptor activity, immune response, and kinetic solubility : the impact of linker chemistry in conjugated NOD2/TLR4 agonists. ACS omega. Aug. 2025, vol. 10, iss. 34, str. 39060-39072, ilustr. ISSN 2470-1343. https://pubs.acs.org/doi/10.1021/acsomega.5c05358, Repozitorij Univerze v Ljubljani – RUL, DOI: 10.1021/acsomega.5c05358. [COBISS.SI-ID 253244675]
projekt: This research was funded by the Slovenian Research and Innovation Agency (P1-0420, J3-4496).

17. HAMERŠAK, Nuša. Proučevanje vpliva vpeljave linearnih in razvejanih maščobnokislinskih ostankov na agonistično aktivnost dezmuramilpeptidov na nukleotid-vezočo oligomerizacijsko domeno vsebujoč protein 2 = Investigating the impact of linear and branched fatty acid residue introduction on nucleotide-binding oligomerization domain protein 2 agonistic activity of desmuramylpeptides : magistrska naloga : enoviti magistrski študijski program Farmacija. Ljubljana: [N. Hameršak], 2025. 1 spletni vir (1 datoteka PDF (IX, 53 str.)), ilustr. https://repozitorij.uni-lj.si/IzpisGradiva.php?id=169458. [COBISS.SI-ID 237883395]

18. BEGUŠ, Maša. Proučevanje vpliva zamenjave homofenilalanina z njegovimi strukturnimi analogi na agonistično aktivnost dezmuramilpeptidov na nukleotid-vezočo oligomerizacijsko domeno vsebujoč protein 2 = Investigation of the impact of homophenylalanine replacement with its structural analogues on the nucleotide-binding oligomerization domain protein 2 agonistic activity of desmuramylpeptides : enovit magistrski študijski program Farmacija. Ljubljana: [M. Beguš], 2025. 1 spletni vir (1 datoteka PDF (VIII, 64 str.)), ilustr. https://repozitorij.uni-lj.si/Iskanje.php?lang=slv#. [COBISS.SI-ID 238662403]

19. PARADISO, Emiliano, JANEŽ, Špela, WEISS, Veronika, FRKANEC, Ruža, JAKOPIN, Žiga (avtor, korespondenčni avtor). Conjugated NOD1-centered dual agonists exhibit modest In vitro immunomodulation but potent in vivo adjuvanticity. ACS bio & med chem au. 2026, vol. , iss. , <v tisku>, ilustr. ISSN 2694-2437. https://pubs.acs.org/doi/10.1021/acsbiomedchemau.6c00080, DOI: 10.1021/acsbiomedchemau.6c00080. [COBISS.SI-ID 281708803]
projekt: This research was funded by the Slovenian Research and Innovation Agency (P1−0420, J3−4496, J3−70142).

20. PETROVIĆ PEROKOVIĆ, Vesna, KOVAČEVIĆ, Monika, CAR, Željka, GRGURIĆ, Dora, JANEŽ, Špela, JAKOPIN, Žiga, MARKULIN, Dora, LOVRIĆ, Marija, ŽUŽIĆ, Marta, RIBIĆ, Rosana (avtor, korespondenčni avtor), et al. Mannose derivatives of ferrocene-containing desmuramyl peptides : synthesis, characterization and in vitro immunological evaluation. Carbohydrate research. Jul. 2026, vol. , 565, [article no.] 109902, str. 1-12, ilustr. ISSN 1873-426X. https://www.sciencedirect.com/science/article/abs/pii/S0008621526000911, DOI: 10.1016/j.carres.2026.109902. [COBISS.SI-ID 273487875]
projekt: This work was supported by the Croatian Science Foundation under the project number IP2020-02-9162 and Slovenian Research and Innovation Agency (P1-0420, J3-4496).

21. JANEŽ, Špela, GUZELJ, Samo, WEISS, Veronika, ŠIŠIĆ, Marcela, FRKANEC, Ruža, PAJK, Stane, BURGMEIJER, Lenny, SLÜTTER, Bram, JAKOPIN, Žiga (avtor, korespondenčni avtor). Probing immune signatures of conjugated pattern recognition receptor ligands Identifies chimeras with potent adjuvant and antitumor activities. Journal of medicinal chemistry. [Online ed.]. 2026, vol. , iss. , <v tisku>, ilustr. ISSN 1520-4804. https://pubs.acs.org/doi/10.1021/acs.jmedchem.6c00372, DOI: 10.1021/acs.jmedchem.6c00372. [COBISS.SI-ID 278080259]
projekt: This work was supported by grants from Slovenian Research and Innovation Agency ARIS to Ž.J. (P1-0420, J3-2517, J3-4496) and Š.J. (Young Researcher’s programme, 56838).