Michael Gütschow

1. ROYDEVA, Polya G., BECKMANN, Anna-Madeleine, STIRNBERG, Marit, CESAR, Jožko, KIKELJ, Danijel, ILAŠ, Janez, GÜTSCHOW, Michael. 3,1-benzothiazines, 1,4-benzodioxines, 1,4-benzoxazines as inhibitors of matriptase-2 : outcome of a focused screening approach. Pharmaceuticals. 2016, vol. 9, issue. 1, 11 str., ilustr. ISSN 1424-8247. http://www.mdpi.com/1424-8247/9/1/2, Repository of the University of Ljubljana – RUL , DOI: 10.3390/ph9010002. [COBISS.SI-ID 4018289]

2. SOSIČ, Izidor, STEINEBACH, Christian, LINDNER, Stefanie, BRICELJ, Aleša, KOHL, Franziska, NG, Yuen Lam Dora, KRÖNKE, Jan, GÜTSCHOW, Michael. A chemical toolbox for cereblon-directed PROTACS. In: Book of abstracts : Joint Symposium on Medicinal Chemistry Frontiers. [S. l.]: [s. n.], 2019. Str. 172. https://www.medchemfrontiers.org/programme. [COBISS.SI-ID 4734065]

3. STEINEBACH, Christian, SOSIČ, Izidor, LINDNER, Stefanie, BRICELJ, Aleša, KOHL, Franziska, NG, Yuen Lam Dora, MONSCHKE, Marius, WAGNER, Karl G., KRÖNKE, Jan, GÜTSCHOW, Michael. A MedChem toolbox for cereblon-directed PROTACs. MedChemComm. 2019, vol. 10, iss. 6, str. 1037-1041, ilustr. ISSN 2040-2503. https://pubs.rsc.org/en/content/articlelanding/2019/md/c9md00185a#!divAbstract, https://pubs.rsc.org/en/content/articlepdf/2019/md/c9md00185a, DOI: 10.1039/C9MD00185A. [COBISS.SI-ID 4723057]

4. BRICELJ, Aleša, LOI, Elena Maria, GOBEC, Martina, STEINEBACH, Christian, GÜTSCHOW, Michael, PIETERS, Roland J., SOSIČ, Izidor, ANDERLUH, Marko. Development of OSMI-4-based biochemical probes for OGT. In: Book of abstracts : 2nd Alpine Winter Conference on Medicinal and Synthetic Chemistry, St. Anton, Austria, 19 - 23, 2020. [S. l.: s. n.], 2020. Str. 94, ilustr. https://www.alpinewinterconference.org/v2/data/1579181858BookAbstracts-Web.pdf. [COBISS.SI-ID 4875377]

5. STEINEBACH, Christian, VOELL, Sabine Anna, PHUONG, Vu Lan, BRICELJ, Aleša, SOSIČ, Izidor, SCHNAKENBURG, Gregor, GÜTSCHOW, Michael. A facile synthesis of ligands for the von Hippel-Lindau E3 ligase. Synthesis. 2020, vol. 52, iss. 17, str. 2521-2527, ilustr. ISSN 0039-7881. https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0040-1707400, DOI: 10.1055/s-0040-1707400. [COBISS.SI-ID 17380355]

6. STEINEBACH, Christian, NG, Yuen Lam Dora, SOSIČ, Izidor, LINDNER, Stefanie, KRÖNKE, Jan, GÜTSCHOW, Michael. Four E3 Ligases, one Target : towards novel CDK6 protacs. In: Book of abstracts : 2nd Alpine Winter Conference on Medicinal and Synthetic Chemistry, St. Anton, Austria, 19 - 23, 2020. [S. l.: s. n.], 2020. Str. 35, ilustr. https://www.alpinewinterconference.org/v2/data/1579181858BookAbstracts-Web.pdf. [COBISS.SI-ID 4875121]

7. SOSIČ, Izidor, GOBEC, Martina, STEINEBACH, Christian, SCHLESINGER, Martin, BENDAS, Gerd, GÜTSCHOW, Michael. Another structural correction for 1-oxo-1H-phenalene-2,3-dicarbonitriles : synthesis of a potent BCL-2 inhibiting 7-phenoxy derivative. Archiv der Pharmazie. 2021, vol. 354, iss. 10, str. 1-13, ilustr. ISSN 1521-4184. https://onlinelibrary.wiley.com/doi/10.1002/ardp.202100151, DOI: 10.1002/ardp.202100151. [COBISS.SI-ID 75619331]
project: J1-2485, P1-0208; funder: ARRS

8. STEINEBACH, Christian, FERBER, D., NG, Yuen Lam Dora, BRICELJ, Aleša, JAMALI, Mina, KUCHTA, Robert, SOSIČ, Izidor, HARTMANN, Marcus, KRÖNKE, Jan, GÜTSCHOW, Michael. Design, synthesis and biomedical investigation of new E3 ligase modulators : poster at Frontiers in Medicinal Chemistry, March 8 - 10, 2021, online : annual meeting. [COBISS.SI-ID 56817667]

9. BRICELJ, Aleša, STEINEBACH, Christian, KUCHTA, Robert, GÜTSCHOW, Michael, SOSIČ, Izidor. E3 ligase ligands in successful PROTACs : an overview of syntheses and linker attachment points. Frontiers in chemistry. [Online ed.]. 2021, vol. 9, str. 1-46, ilustr. ISSN 2296-2646. https://www.frontiersin.org/articles/10.3389/fchem.2021.707317/full, DOI: 10.3389/fchem.2021.707317. [COBISS.SI-ID 75626755]

10. BRICELJ, Aleša, NG, Yuen Lam Dora, FERBER, D., KUCHTA, Robert, MÜLLER, Sina, MONSCHKE, Marius, WAGNER, Karl G., KRÖNKE, Jan, SOSIČ, Izidor, GÜTSCHOW, Michael, STEINEBACH, Christian. Influence of linker attachment points on the stability and neosubstrate degradation of cereblon ligands. ACS Medicinal Chemistry Letters. 2021, vol. 12, iss. 11, str. 1733-1738, ilustr. ISSN 1948-5875. https://pubs.acs.org/doi/10.1021/acsmedchemlett.1c00368, DOI: 10.1021/acsmedchemlett.1c00368. [COBISS.SI-ID 81287683]
project: P1-0208 Grant J1-2485 to I.S.; funder: This work was supported by the DFG (Emmy-Noether Program Kr-3886/2-1 and SFB-1074 to J.K.), the ARRS, and the German Academic Scholarship Foundation

11. STEINEBACH, Christian, NG, Yuen Lam Dora, BRICELJ, Aleša, SOSIČ, Izidor, KRÖNKE, Jan, GÜTSCHOW, Michael. PROTAC-mediated inactivation of e3 ligases : from tools to cancer treatment. In: Book of abstracts. 2021. Str. 156, po96, ilustr. https://www.efmc-ymcs.org/v2/data/1630930688BookYMCS-Virtual-HD.pdf. [COBISS.SI-ID 76063491]

12. STEINBACHER, Christian, NG, Yuen Lam Dora, BRICELJ, Aleša, SOSIČ, Izidor, KRÖNKE, Jan, GÜTSCHOW, Michael. Protac-mediated inactivation of e3 ligases: from tools to cancer treatment. In: Book of abstracts. 2021. Str. 291, m052. https://www.efmc-ismc.org/v2/data/1630081893EFMC-ISMC-BookOfAbstracts-webHD.pdf. [COBISS.SI-ID 74933251]

13. SOSIČ, Izidor, STEINEBACH, Christian, BRICELJ, Aleša, NG, Y.L.D., GOBEC, Martina, KRÖNKE, Jan, PIETERS, Roland J., ANDERLUH, Marko, GÜTSCHOW, Michael. PROTACS as tools for the modulation of pharmacological targets : presented at early bird sessions on 45th FEBS Congress, Molecules of Life: Towards New Horizons, Ljubljana, Slovenia, July 3-8, 2021. FEBS open bio. 2021, vol. 11, suppl. s1, str. 100. ISSN 2211-5463. https://febs.onlinelibrary.wiley.com/doi/epdf/10.1002/2211-5463.13206, DOI: 10.1002/2211-5463.13206. [COBISS.SI-ID 70178051]

14. VU, L. P., STEINEBACH, Christian, BRICELJ, Aleša, SOSIČ, Izidor, GÜTSCHOW, Michael. Synthesis of novel building blocks for VHL-based PROTACs : poster at Frontiers in Medicinal Chemistry, March 8 - 10, 2021, online : annual meeting. [COBISS.SI-ID 56807427]

15. GOCKEL, Lukas Maria, PFEIFER, Vladlena, BALTES, Fabian, BACHMAIER, Rafael D., WAGNER, Karl G., BENDAS, Gerd, GÜTSCHOW, Michael, SOSIČ, Izidor, STEINEBACH, Christian. Design, synthesis, and characterization of PROTACs targeting the androgen receptor in prostate and lung cancer models. Archiv der Pharmazie. 2022, vol. 355, iss. 5, e2100467, str. 1-15, ilustr. ISSN 1521-4184. https://onlinelibrary.wiley.com/doi/full/10.1002/ardp.202100467, DOI: 10.1002/ardp.202100467. [COBISS.SI-ID 96807683]
project: J1-2485, P1-0208; funder: Javna Agencija za Raziskovalno Dejavnost RS

16. MILLER, Daniel H., VOELL, Sabine Anna, SOSIČ, Izidor, PROJ, Matic, ROSSANESE, Olivia, SCHNAKENBURG, Gregor, GÜTSCHOW, Michael, COLLINS, Ian, STEINEBACH, Christian. Encoding BRAF inhibitor functions in protein degraders. RSC medicinal chemistry. 2022, vol. 13, iss. 6, str. 731-736, ilustr. ISSN 2632-8682. https://pubs.rsc.org/en/content/articlepdf/2022/md/d2md00064d, https://www.rsc.org/suppdata/d2/md/d2md00064d/d2md00064d1.pdf, DOI: 10.1039/D2MD00064D. [COBISS.SI-ID 106746115]
project: C309/11566; funder: Cancer Research UK programme
project: P1-0208; funder: ARRS
project: J1-2485; funder: ARRS

17. BRICELJ, Aleša, NG, Yuen Dora, JANSEN, Jacqueline, KRÖNKE, Jan, GÜTSCHOW, Michael, STEINEBACH, Christian, SOSIČ, Izidor. Heterobifunctional E3 ligase recruiters for PAN-degradation of inhibitor of apoptosis proteins. In: Book of abstracts. [S. l.]: [s. n.], 2022. Str. 131, p022. https://www.efmc-ismc.org/v2/data/1661849465EFMC-ISMC-Book-Web-HD3.pdf. [COBISS.SI-ID 121076739]

18. MURGAI, Arunima, SOSIČ, Izidor, GOBEC, Martina, LEMNITZER, Patricia, PROJ, Matic, WITTENBURG, Sophie, VOGET, Rabea, GÜTSCHOW, Michael, KRÖNKE, Jan, STEINEBACH, Christian. Targeting the deubiquitinase USP7 for degradation with PROTACs. Chemical communications. [Online ed.]. 2022, vol. 58, iss. 63, str. 8858-8861, ilustr. ISSN 1364-548X. https://pubs.rsc.org/en/content/articlelanding/2022/cc/d2cc02094g, DOI: 10.1039/D2CC02094G. [COBISS.SI-ID 115213571]
project: P1-0208; funder: ARRS
project: J1-2485; funder: ARRS
project: Kr-3886/2-1; funder: DFG
project: SFB-1074; funder: DFG
project: CA214608; funder: Costa action
project: CA218278; funder: Cost action

19. KUCHTA, Robert, HEIM, Christopher, HERRMANN, Alexander, MAIWALD, Samuel, NG, Yuen Lam Dora, SOSIČ, Izidor, KEULER, Tim, KRÖNKE, Jan, GÜTSCHOW, Michael, HARTMANN, Marcus D., STEINEBACH, Christian. Accessing three-branched high-affinity cereblon ligands for molecular glue and protein degrader design. RSC chemical biology. 2023, vol. 4, iss. 3, str. 229-234, ilustr. ISSN 2633-0679. https://pubs.rsc.org/en/content/articlelanding/2023/cb/d2cb00223j, Repository of the University of Ljubljana – RUL , DOI: 10.1039/D2CB00223J. [COBISS.SI-ID 136507395]
project: Kr-3886/2-1; funder: DFG
project: SFB-1074; funder: DFG
project: P1-0208; funder: ARRS
project: J1-2485; funder: ARRS
project: CA214608; funder: NIH
project: CA218278; funder: NIH

20. BRICELJ, Aleša, NG, Yuen Dora, JANSEN, Jacqueline A., MURGAI, Arunima, KRÖNKE, Jan, PETER, Kirsten, DONOVAN, Katherine A., GÜTSCHOW, Michael, STEINEBACH, Christian, SOSIČ, Izidor. Battle of the E3 ligases : using heteroprotacs to induce pan-iap degradation. In: JAKOPIN, Žiga (ed.), TOMAŠIČ, Tihomir (ed.). Crossing the Boundaries of Medicinal Chemistry : book of abstracts : University of Ljubljana, Faculty of Pharmacy, September 28, 2023. Ljubljana: Fakulteta za farmacijo, 2023. Str. 7-8, ilustr. ISBN 978-961-6378-95-6. https://www.ffa.uni-lj.si/docs/default-source/e-knjige/book-of-abstracts---crossing-the-boundaries-of-medicinal-chemistry.pdf?sfvrsn=2. [COBISS.SI-ID 173398787]

21. BRICELJ, Aleša, NG, Yuen Lam Dora, JANSEN, Jacqueline A., MURGAI, Arunima, KRÖNKE, Jan, PETER, Kirsten, DONOVAN, Katherine A., GÜTSCHOW, Michael, STEINEBACH, Christian, SOSIČ, Izidor. Heterobifunctional E3 ligase recruiters enable pan-degradation of inhibitor of apoptosis proteins. In: Book of abstracts. [S. l.]: [s. n.], 2023. Str. 123, p033, ilustr. https://www.efmc-asmc.org/content.php?langue=english&cle_menus=1238917879. [COBISS.SI-ID 164222467]

22. BRICELJ, Aleša, NG, Yuen Lam Dora, JANSEN, Jacqueline A., MURGAI, Arunima, KRÖNKE, Jan, PETER, Kirsten, DONOVAN, Katherine A., GÜTSCHOW, Michael, STEINEBACH, Christian, SOSIČ, Izidor. Heterobifunctional E3 ligase recruiters enable pan-degradation of inhibitor of apoptosis proteins. In: Book of abstracts. 2022. Str. 33, oc12, ilustr. https://www.efmc.info/cust_events.php?langue=english&cle_menus=1187970268. [COBISS.SI-ID 169682435]

23. NG, Yuen Lam Dora, BRICELJ, Aleša, JANSEN, Jacqueline A., MURGAI, Arunima, PETER, Kirsten, DONOVAN, Katherine A., GÜTSCHOW, Michael, KRÖNKE, Jan, STEINEBACH, Christian, SOSIČ, Izidor. Heterobifunctional ligase recruiters enable pan-degradation of inhibitor of apoptosis proteins. Journal of medicinal chemistry. [Online ed.]. 2023, vol. 66, iss. 7, str. 4703-4733, ilustr. ISSN 1520-4804. https://pubs.acs.org/doi/10.1021/acs.jmedchem.2c01817, Repository of the University of Ljubljana – RUL , DOI: 10.1021/acs.jmedchem.2c01817. [COBISS.SI-ID 147303683]
award: Članek je prejel Dekanovo nagrado2023

24. BRICELJ, Aleša, NG, Yuen Dora, JANSEN, Jacqueline A., KRÖNKE, Jan, GÜTSCHOW, Michael, ANDERLUH, Marko, STEINEBACH, Christian, SOSIČ, Izidor. Lessons learned from successes and struggles in implementing protac methodology for a panel of proteins involved in malignancies. In: Book of abstracts. Medicinal Chemistry Frontiers 2023 Boston, MA, United States June 10-13, 2023. [S. l.]: [s. n.], 2023. Str. 104, p011. https://www.medchemfrontiers.org/auth.php?langue=english&cle_menus=1049119092&ant_file_redirect=https%3A%2F%2Fwww.medchemfrontiers.org%2Fcontent.php%3Flangue%3Denglish%26cle_menus%3D1238917781. [COBISS.SI-ID 158405379]

25. WITTENBURG, Sophie, MURGAI, Arunima, KRÖNKE, Jan, SOSIČ, Izidor, GÜTSCHOW, Michael, STEINEBACH, Christian. Design and synthesis of novel USP7-targeting protacs. In: Book of abstracts : 4th Alpine Winter Conference on Medicinal and Synthetic Chemistry, St. Anton, Austria, January 28-February 1, 2024. [S. l.: s. n.], 2024. Str. 110, p025, ilustr. https://www.alpinewinterconference.org/auth.php?langue=english&cle_menus=1049119092&ant_file_redirect=content.php%3Flangue%3Denglish%26amp%3Bcle_menus%3D1238918051. [COBISS.SI-ID 199448067]

26. BRICELJ, Aleša, NG, Yuen Lam Dora, GOBEC, Martina, KUCHTA, Robert, HU, Wanyi, JAVORNIK, Špela, ROŽIČ, Miha, GÜTSCHOW, Michael, ZHENG, Guangrong, SOSIČ, Izidor, et al. Design, synthesis, and evaluation of BCL-2 targeting PROTACs. Chemistry : a European journal. [Online ed.]. 2024, vol. 30, iss. 45, [article no. e202400430], 8 str., ilustr. ISSN 1521-3765. https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/chem.202400430, DOI: 10.1002/chem.202400430. [COBISS.SI-ID 197511171]
project: We acknowledge support by the SlovenianResearch Agency (ARRS) (Program P1-0208 andGrant J1-2485 to I.S.), the German ResearchFoundation (DFG) (Kr-3886/8 and SFB-1074 toJ.K.; STE 3140/1-1 to C.S.), and the NationalInstitute of Health (NIH) (R01 CA241191 to G.Z.).

27. STRAŠEK BENEDIK, Nika, BRICELJ, Aleša, GOBEC, Martina, GÜTSCHOW, Michael, STEINEBACH, Christian, SOSIČ, Izidor. Development of first-in-class TAK1 degraders. In: Protein Degradation in Focus : A Special Symposium to Celebrate the Opening of CeTPD in Dundee 19th – 22nd May 2024 University of Dundee, UK : programme & abstracts. A Special Symposium to Celebrate the Opening of CeTPD in Dundee 19th – 22nd May 2024 University of Dundee. Dundee: University of Dundee, UK, 2024. Str. 175. https://www.dundee.ac.uk/events/protein-degradation-focus-symposium. [COBISS.SI-ID 195891715]

28. STEINEBACH, Christian, WITTENBURG, Sophie, MURGAI, Arunima, SOSIČ, Izidor, KRÖNKE, Jan, GÜTSCHOW, Michael. Discovery of PROTACs directed against the deubiquitinase USP7. In: Protein Degradation in Focus : A Special Symposium to Celebrate the Opening of CeTPD in Dundee 19th – 22nd May 2024 University of Dundee, UK : programme & abstracts. A Special Symposium to Celebrate the Opening of CeTPD in Dundee 19th – 22nd May 2024 University of Dundee. Dundee: University of Dundee, UK, 2024. Str. 176. https://www.dundee.ac.uk/events/protein-degradation-focus-symposium. [COBISS.SI-ID 195892483]

29. SIEVERS, Johannes, NG, Yuen Lam Dora, BRICELJ, Aleša, LU, Feiteng, KROLS, Simon, KRÖNKE, Jan, VAN CALENBERGH, Serge, GÜTSCHOW, Michael, SOSIČ, Izidor, STEINEBACH, Christian. Medicinal chemistry approaches towards BCL-2-selective degraders. In: Book of abstracts : EFMC-ASMC International Symposium on Advances in Synthetic and Medicinal Chemistry Porto, Portugal August 31-September 4, 2025. [S. l.: s. n.], 2025. Str. 438, p352, ilustr. https://www.efmc-asmc.org/programme. [COBISS.SI-ID 250753539]

30. MUFFEL, T., ZHAI, S., HANSEN, F. K., SOSIČ, Izidor, GÜTSCHOW, Michael, STEINEBACH, Christian. Novel KEAP1-recruiting Ligands for PROTAC Development. In: Frontiers in Medicinal Chemistry, April 1 - 4, 2025 - Erlangen, Germany : poster program. [S. l.]: [s. n.], 2025. Str. 81. https://veranstaltungen.gdch.de/microsite/index.cfm?l=11738&modus=. [COBISS.SI-ID 230663427]