Anna Więckowska

1. BRUS, Boris, KOŠAK, Urban, KNEZ, Damijan, COQUELLE, Nicolas, ŽIVIN, Marko, SALAT, Kinga, PODKOWA, Adrian, FILIPEK, Barbara, WIĘCKOWSKA, Anna, MALAWSKA, Barbara, STOJAN, Jure, COLLETIER, Jacques-Philippe, GOBEC, Stanislav. Discovery of nanomolar inhibitors of butyrycholinesterase. In: IXthe Joint Meeting in Medicinal Chemistry, 7-10 June 2015, Athens, Greece : program. Athens: [s. n.], 2015. 1 str. http://www.efmc.info/infos.php?langue=english&cle_menus=1201086332&cle_data=1417004654. [COBISS.SI-ID 3997553]

2. WIĘCKOWSKA, Anna, WIĘCKOWSKI, Krzysztof, BAJDA, Marek, BRUS, Boris, SAŁAT, Kinga, CZERWIŃSKA, Paulina, GOBEC, Stanislav, FILIPEK, Barbara, MALAWSKA, Barbara. Synthesis of new N-benzylpiperidine derivatives as cholinesterase inhibitors with ß-amyloid anti-aggregation properties and beneficial effects on memory in vivo. Bioorganic & Medicinal Chemistry. [Print ed.]. 2015, vol. 23, iss. 10, str. 2445-2457, ilustr. ISSN 0968-0896. http://www.sciencedirect.com/science/article/pii/S0968089615002473#, DOI: 10.1016/j.bmc.2015.03.051. [COBISS.SI-ID 3833713]

3. KOŠAK, Urban, BRUS, Boris, KNEZ, Damijan, ŠINK, Roman, ŽAKELJ, Simon, TRONTELJ, Jurij, PIŠLAR, Anja, ŠLENC, Jasna, GOBEC, Martina, ŽIVIN, Marko, TRATNJEK, Larisa, PERŠE, Martina, SAŁAT, Kinga, PODKOWA, Adrian, FILIPEK, Barbara, NACHON, Florian, BRAZZOLOTTO, Xavier, WIĘCKOWSKA, Anna, MALAWSKA, Barbara, STOJAN, Jure, MLINARIČ-RAŠČAN, Irena, KOS, Janko, COQUELLE, Nicolas, COLLETIER, Jacques-Philippe, GOBEC, Stanislav. Development of an in-vivo active reversible butyrylcholinesterase inhibitor. Scientific reports. Dec.. 2016, vol. 6, str. 1-16, ilustr. ISSN 2045-2322. http://www.nature.com/articles/srep39495, DOI: 10.1038/srep39495. [COBISS.SI-ID 4263537]

4. WIĘCKOWSKA, Anna, KOŁACZKOWSKI, Marcin, BUCKI, Adam, GODYŃ, Justyna, MARCINKOWSKA, Monika, WIĘCKOWSKI, Krzysztof, ZARĘBA, Paula, SIWEK, Agata, KAZEK, Grzegorz, GŁUCH-LUTWIN, Monika, MIERZEJEWSKI, Paweł, BIENKOWSKI, Przemysław, SIENKIEWICZ-JAROSZ, Halina, KNEZ, Damijan, WICHUR, Tomasz, GOBEC, Stanislav, MALAWSKA, Barbara. Novel multi-target-directed ligands for Alzheimer's disease : combining cholinesterase inhibitors and 5-HT6 receptor antagonists. Design, synthesis and biological evaluation. European journal of medicinal chemistry. [Print ed.]. 29 Nov. 2016, vol. 124, str. 63-81, ilustr. ISSN 0223-5234. http://www.sciencedirect.com/science/article/pii/S0223523416306596, DOI: 10.1016/j.ejmech.2016.08.016. [COBISS.SI-ID 4144753]

5. HEBDA, Michalina, BAJDA, Marek, WIĘCKOWSKA, Anna, SZAŁAJ, Natalia, PASIEKA, Anna, PANEK, Dawid, GODYŃ, Justyna, WICHUR, Tomasz, KNEZ, Damijan, GOBEC, Stanislav, MALAWSKA, Barbara. Synthesis, molecular modelling and biological evaluation of novel heterodimeric, multiple ligands targeting cholinesterases and amyloid beta. Molecules. 2016, vol. 21, iss. 4, str. 1-24, ilustr. ISSN 1420-3049. http://www.mdpi.com/1420-3049/21/4/410, Repozitorij Univerze v Ljubljani – RUL, DOI: 10.3390/molecules21040410. [COBISS.SI-ID 4051313]

6. PANEK, Dawid, WIĘCKOWSKA, Anna, WICHUR, Tomasz, BAJDA, Marek, GODYŃ, Justyna, JOŃCZYK, Jakub, MIKA, Kamil, JANOCKOVA, Jana, SOUKUP, Ondrej, KNEZ, Damijan, KORABECNY, Jan, GOBEC, Stanislav, MALAWSKA, Barbara. Design, synthesis and biological evaluation of new phthalimide and saccharin derivatives with alicyclic amines targeting cholinesterases, beta-secretase and amyloid beta aggregation. European journal of medicinal chemistry. [Print ed.]. Jan. 2017, vol. 125, str. 676-695, ilustr. ISSN 0223-5234. http://www.sciencedirect.com/science/article/pii/S0223523416308169, DOI: 10.1016/j.ejmech.2016.09.078. [COBISS.SI-ID 4223601]

7. PANEK, Dawid, WIĘCKOWSKA, Anna, JOŃCZYK, Jakub, GODYŃ, Justyna, BAJDA, Marek, WICHUR, Tomasz, PASIEKA, Anna, KNEZ, Damijan, PIŠLAR, Anja, KORABECNY, Jan, SOUKUP, Ondrej, SEPSOVA, Vendula, SABATÉ, Raimon, KOS, Janko, GOBEC, Stanislav, MALAWSKA, Barbara. Design, synthesis and biological evaluation of 1-benzylamino-2-hydroxyalkyl derivatives as new potential disease-modifying multifunctional anti-Alzheimer's agents. ACS chemical neuroscience. 2018, vol. 9, issue 5, str. 1074-1094, tabele, ilustr. ISSN 1948-7193. http://pubs.acs.org/doi/10.1021/acschemneuro.7b00461, DOI: 10.1021/acschemneuro.7b00461. [COBISS.SI-ID 4465009]

8. PANEK, Dawid, WIĘCKOWSKA, Anna, PASIEKA, Anna, GODYŃ, Justyna, JOŃCZYK, Jakub, BAJDA, Marek, KNEZ, Damijan, GOBEC, Stanislav, MALAWSKA, Barbara. Design, synthesis, and biological evaluation of 2-(benzylamino-2-hydroxyalkyl)isoindoline-1,3-diones derivatives as potential disease-modifying multifunctional anti-Alzheimer agents. Molecules. 2018, vol. 23, iss. 2, str. 1-15, ilustr. ISSN 1420-3049. http://www.mdpi.com/1420-3049/23/2/347, Repozitorij Univerze v Ljubljani – RUL, DOI: 10.3390/molecules23020347. [COBISS.SI-ID 4473713]

9. WIĘCKOWSKA, Anna, WICHUR, Tomasz, GODYŃ, Justyna, PANEK, Dawid, JOŃCZYK, Jakub, KNEZ, Damijan, GOBEC, Stanislav, et al. Multi-target-directed ligands with potential disease modifying and symptomatic effects in Alzheimer's disease. In: ANDERLUH, Marko (ed.). Book of abstracts. XXV International Symposium on Medicinal Chemistry, Ljubljana, Slovenia, September 2 - 6, 2018. Ljubljana: Slovensko farmacevtsko društvo, 2018. Str. 207, p164, ilustr. [COBISS.SI-ID 4586609]

10. WIĘCKOWSKA, Anna, WICHUR, Tomasz, GODYŃ, Justyna, BUCKI, Adam, MARCINKOWSKA, Monika, KNEZ, Damijan, GOBEC, Stanislav, et al. Novel multi-target-directed ligands aiming at symptoms and causes of Alzheimer's disease. ACS chemical neuroscience. 2018, vol. 9, iss. 5, str. 1195-1214, tabele, ilustr. ISSN 1948-7193. https://pubs.acs.org/doi/10.1021/acschemneuro.8b00024, DOI: 10.1021/acschemneuro.8b00024. [COBISS.SI-ID 4470641]

11. PANEK, Dawid, PASIEKA, Anna, SZAŁAJ, Natalia, GODYŃ, Justyna, JOŃCZYK, Jakub, KNEZ, Damijan, WIĘCKOWSKA, Anna, BAJDA, Marek, GOBEC, Stanislav, MALAWSKA, Barbara. Beta-secretase and butyrylcholinesterase inhibitors as potential multi-targeted ligands against Alzheimer's disease. In: Book of abstracts : Joint Symposium on Medicinal Chemistry Frontiers. [S. l.]: [s. n.], 2019. Str. 177, ilustr. https://www.medchemfrontiers.org/programme. [COBISS.SI-ID 4733297]

12. PASIEKA, Anna, PANEK, Dawid, SZAŁAJ, Natalia, GODYŃ, Justyna, JOŃCZYK, Jakub, TABOR, J., KNEZ, Damijan, WIĘCKOWSKA, Anna, BAJDA, Marek, GOBEC, Stanislav, MALAWSKA, Barbara. Novel 1-amino-4-phenylbutan-2-ol derivatives as multifunctional ligands inhibiting butyrylcholinesterase and beta-secretase. In: KRÁTKÝ, Martin (ed.), ZITKO, Jan (ed.), NENCKA, Radim (ed.). New molecules : towards the Drugs of the Future - selected papers from JMMC 2019 : final progamme. Basel: MDPI AG, 2019. 1 str. Biomolecules. ISSN 2218-273X. https://guarant.eu/jmmc2019/files/jmmc-2019-final-programme.pdf. [COBISS.SI-ID 4751985]

13. WICHUR, Tomasz, GODYŃ, Justyna, SIWEK, Agata, GŁUCH-LUTWIN, Monika, KNEZ, Damijan, BUCKI, Adam, KOŁACZKOWSKI, Marcin, GOBEC, Stanislav, MALAWSKA, Barbara, WIĘCKOWSKA, Anna. Targeting serotoninergic system cholinesterases and amyloid-beta aggregation in the search for effective treatment of Alzheimer's disease. In: Book of abstracts : Joint Symposium on Medicinal Chemistry Frontiers. [S. l.]: [s. n.], 2019. Str. 189, ilustr. https://www.medchemfrontiers.org/programme. [COBISS.SI-ID 4733809]

14. WICHUR, Tomasz, WIĘCKOWSKA, Anna, WIĘCKOWSKI, Krzysztof, GODYŃ, Justyna, JOŃCZYK, Jakub, DEL RÍO VALDIVIESO, Álvaro, PANEK, Dawid, PASIEKA, Anna, KNEZ, Damijan, GOBEC, Stanislav, et al. 1-benzylpyrrolidine-3-amine-based BuChE inhibitors with anti-aggregating, antioxidant and metal-chelating properties as multifunctional agents against Alzheimer's disease. European journal of medicinal chemistry. [Print ed.]. Feb. 2020, vol. 187, str. 1-18, ilustr. ISSN 0223-5234. https://www.sciencedirect.com/science/article/pii/S0223523419310682?via%3Dihub, DOI: 10.1016/j.ejmech.2019.111916. [COBISS.SI-ID 4857713]

15. SZAŁAJ, Natalia, GODYŃ, Justyna, JOŃCZYK, Jakub, PASIEKA, Anna, PANEK, Dawid, WICHUR, Tomasz, WIĘCKOWSKI, Krzysztof, ZARĘBA, Paula, BAJDA, Marek, PIŠLAR, Anja, MALAWSKA, Barbara, SABATÉ, Raimon, WIĘCKOWSKA, Anna. Multidirectional in vitro and in cellulo studies as a tool for identification of multi-target-directed ligands aiming at symptoms and causes of Alzheimer's disease. Journal of enzyme inhibition and medicinal chemistry. 2020, vol. 35, iss. 1, str. 1944-1952, ilustr. ISSN 1475-6374. https://www.tandfonline.com/doi/full/10.1080/14756366.2020.1835882, DOI: 10.1080/14756366.2020.1835882. [COBISS.SI-ID 36188163]
project: funder: Slovenian Research Agency

16. MALAWSKA, Barbara, PANEK, Dawid, PASIEKA, Anna, WICHUR, Tomasz, JOŃCZYK, Jakub, GODYŃ, Justyna, WIĘCKOWSKA, Anna, SZAŁAJ, Natalia, BAJDA, Marek, KNEZ, Damijan, GOBEC, Stanislav, SABATÉ, Raimon. Multifunctional anti-Alzheimer's agents with anti-aggregating properties targeting neurotoxic beta-amyloid peptide and Tau protein. In: COST ACTION CA15135 : final status of WG activities within the MuTaLig COST Action : book of the abstracts. Fourth WG Meeting CA15135, Ege University, Faculty of Pharmacy, Bornova, İzmir, Pearl of the Aegean March 5th - 6th 2020. [S. l.: s. n. ], 2020. Str. 48. http://www.mutalig.eu/2019/12/4th-wg-meeting-final-status-of-wg-activities-within-the-mutalig-cost-action-ege-university-izmir-turkey-march-5th-6th-2020/. [COBISS.SI-ID 4900721]

17. BAUTISTA-AGUILERA, Oscar M., MANIK, Aleksandra, DIEZ-IRIEPA, Daniel, SZAŁAJ, Natalia, ZARĘBA, Paula, WIĘCKOWSKA, Anna, ŽMUDZKI, Paweł, HONKISZ-ORZECHOWSKA, Ewelina, KNEZ, Damijan, GOBEC, Stanislav, et al. N-Methyl-N-((1-methyl-5-(3-(piperidin-1-yl)propoxy)-1H-benzo[d]imidazol-2-yl)methyl)prop-2-yn-1-amine (MBA-159), a new multitarget small molecule for the therapy of Alzheimer’s disease. Biomedicine & pharmacotherapy. [Print ed.]. 2025, vol. 192, [article no.] 118603, str. 1-17, graf. prikazi. ISSN 0753-3322. https://www.sciencedirect.com/science/article/pii/S0753332225007978, DOI: 10.1016/j.biopha.2025.118603. [COBISS.SI-ID 252870403]
project: II thanks AEI (Government of Spain; Grant PID2019–105813RB-C22). JMC thanks AEI (Government of Spain; Grant PID2019–105813RB-C21) and UCJC [Grant: “In vivo analysis of new analogues of Contilisant (MITOPI) (2022)”] for support. This study was also supported by the Ministerio de Economía, Industria y Competitividad (Agencia Estatal de Investigación, AEI; to CGF, and MP) and Fondo Europeo de Desarrollo Regional (MINECO-FEDER) (PID2022–139016OA-I00, PDC2022–133441-I00, to CGF, and MP), Generalitat de Catalunya (2021 SGR 00357; to CGF and MP). This study was co-financed by Secretaria d’Universitats i Recerca del Departament d’Empresa i Coneixement de la Generalitat de Catalunya 2022 (Producte 0092; Llavor 005 and 007; to CGF). The Government of Catalonia (2021 SGR 00357 to C.G.-F and M.P.). II and OMBA thank Laura Contreras and Cristina García for their collaboration. II and OMBA thank subsidies for the implementation of the research program within the framework of the recovery, transformation and resilience plan – financed by the European Union – Next Generation EU. CAM. K.S. and E.H.-O. thank JUMC for support (Grant N42/DBS/000290 and N42/DBS/000332). ADMET studies were financed by the National Science Centre Poland (Grant No. 2019/34/E/NZ7/00090). The ADMET research/study were carried out with the use of research infrastructure co-financed by the Smart Growth Operational Programme POIR 4.2 project no. POIR.04.02.00–00-D023/20. The financial support from the Slovenian Research and Innovation Agency (Research Core Funding grant P1–0208) is gratefully acknowledged. This research was supported by the Ministry of Education, Science, and Sport (MIZŠ) and the European Regional Development Fund OP20.05187 RI-SI-EATRIS. BMA, VGH, CTS and GTD, thanks UAH CEA and CEMAETA CAI for the in vivo pharmacokinetics studies which were carried out with the use of their research infrastructure.