Nicolas Coquelle

1. BRUS, Boris, KOŠAK, Urban, TURK, Samo, PIŠLAR, Anja, COQUELLE, Nicolas, KOS, Janko, STOJAN, Jure, COLLETIER, Jacques-Philippe, GOBEC, Stanislav. Discovery, biological evaluation, and crystal structure of a novel nanomolar selective butyrylcholinesterase inhibitor : [kratko predavanje]. In: ANDERLUH, Gregor (ed.), KRAŠEVEC, Nada (ed.). Molekulske interakcije : 10 let Infrastrukturnega centra za raziskave molekulskih interakcij : mini simpozij 2014, 3. 12. 2014, Ljubljana. Ljubljana: Laboratorij za molekularno biologijo in nanobiotehnologijo, Kemijski inštitut, 2014. Str. 28, ilustr. ISBN 978-961-6104-27-2. [COBISS.SI-ID 3786609]

2. BRUS, Boris, KOŠAK, Urban, TURK, Samo, PIŠLAR, Anja, COQUELLE, Nicolas, KOS, Janko, STOJAN, Jure, COLLETIER, Jacques-Philippe, GOBEC, Stanislav, et al. Discovery, biological evaluation, and crystal structure of a novel nanomolar selective butyrylcholinesterase inhibitor. Journal of medicinal chemistry. 2014, vol. 57, issue 19, str. 8167-8179, ilustr. ISSN 0022-2623. http://pubs.acs.org/action/doSearch?text1=Discovery%2C+Biological+Evaluation%2C+and+Crystal+Structure+of+a+Novel+Nanomolar+Selective+Butyrylcholinesterase+Inhibitor&field1=Title, http://pubs.acs.org/doi/pdf/10.1021/jm501195e, DOI: 10.1021/jm501195e. [COBISS.SI-ID 3713393]

3. BRUS, Boris, KOŠAK, Urban, KNEZ, Damijan, COQUELLE, Nicolas, ŽIVIN, Marko, SALAT, Kinga, PODKOWA, Adrian, FILIPEK, Barbara, WIĘCKOWSKA, Anna, MALAWSKA, Barbara, STOJAN, Jure, COLLETIER, Jacques-Philippe, GOBEC, Stanislav. Discovery of nanomolar inhibitors of butyrycholinesterase. In: IXthe Joint Meeting in Medicinal Chemistry, 7-10 June 2015, Athens, Greece : program. Athens: [s. n.], 2015. 1 str. http://www.efmc.info/infos.php?langue=english&cle_menus=1201086332&cle_data=1417004654. [COBISS.SI-ID 3997553]

4. KNEZ, Damijan, BRUS, Boris, COQUELLE, Nicolas, SOSIČ, Izidor, ŠINK, Roman, BRAZZOLOTTO, Xavier, MRAVLJAK, Janez, COLLETIER, Jacques-Philippe, GOBEC, Stanislav. Structure-based development of nitroxoline derivatives as potential multifunctional anti-Alzheimer agents. Bioorganic & Medicinal Chemistry. [Print ed.]. Aug. 2015, vol. 23, iss. 15, str. 4442-4452, ilustr. ISSN 0968-0896. http://www.sciencedirect.com/science/article/pii/S0968089615005040#, DOI: 10.1016/j.bmc.2015.06.010. [COBISS.SI-ID 3874161]

5. BRUS, Boris, KOŠAK, Urban, KNEZ, Damijan, COQUELLE, Nicolas, COLLETIER, Jacques-Philippe, GOBEC, Stanislav. 1,3- in 1,4-disubstituirani piperidini kot zaviralci butirilholin-esteraze za zdravljenje Alzheimerjeve bolezni in ostalih demenc : 24951 (A), 2016-09-30. Ljubljana: Urad Republike Slovenije za intelektualno lastnino, 2016. 50 str., ilustr. http://www2.uil-sipo.si/ds1.htm?A=107000&Q=NUM%3D201500076. [COBISS.SI-ID 4223857]
patent family: Številka prijave: 201500076; Številka patenta: 24951 (A), 2016-09-30

6. KOŠAK, Urban, BRUS, Boris, KNEZ, Damijan, ŠINK, Roman, ŽAKELJ, Simon, TRONTELJ, Jurij, PIŠLAR, Anja, ŠLENC, Jasna, GOBEC, Martina, ŽIVIN, Marko, TRATNJEK, Larisa, PERŠE, Martina, SAŁAT, Kinga, PODKOWA, Adrian, FILIPEK, Barbara, NACHON, Florian, BRAZZOLOTTO, Xavier, WIĘCKOWSKA, Anna, MALAWSKA, Barbara, STOJAN, Jure, MLINARIČ-RAŠČAN, Irena, KOS, Janko, COQUELLE, Nicolas, COLLETIER, Jacques-Philippe, GOBEC, Stanislav. Development of an in-vivo active reversible butyrylcholinesterase inhibitor. Scientific reports. Dec.. 2016, vol. 6, str. 1-16, ilustr. ISSN 2045-2322. http://www.nature.com/articles/srep39495, DOI: 10.1038/srep39495. [COBISS.SI-ID 4263537]

7. KOŠAK, Urban, KNEZ, Damijan, BRUS, Boris, PIŠLAR, Anja, ŽAKELJ, Simon, TRONTELJ, Jurij, STOJAN, Jure, ŽIVIN, Marko, PODKOWA, Adrian, SAŁAT, Kinga, COQUELLE, Nicolas, COLLETIER, Jacques-Philippe, GOBEC, Stanislav. Development of in vivo active non - covalent butyrycholinesterase inhibitors. In: KLJUN, Jakob (ed.), GABER, Aljaž (ed.). Book of abstracts. Scientific Conference for Young Researchers, 19. 9. 2017. Ljubljana: Fakulteta za kemijo in kemijsko tehnologijo, 2017. Str. 10, ilustr. ISBN 978-961-6756-83-9. [COBISS.SI-ID 4405105]

8. KOŠAK, Urban, KNEZ, Damijan, COQUELLE, Nicolas, BRUS, Boris, PIŠLAR, Anja, NACHON, Florian, BRAZZOLOTTO, Xavier, KOS, Janko, COLLETIER, Jacques-Philippe, GOBEC, Stanislav. N-propargylpiperidines with naphthalene-2-carboxamide or naphthalene-2- sulfonamide moieties. Bioorganic & Medicinal Chemistry. [Print ed.]. 2017, vol. 25, iss. 2, str. 633-645, ilustr. ISSN 0968-0896. http://www.sciencedirect.com/science/article/pii/S0968089616309099, DOI: 10.1016/j.bmc.2016.11.032. [COBISS.SI-ID 4248177]

9. KNEZ, Damijan, KOŠAK, Urban, BRUS, Boris, PIŠLAR, Anja, COQUELLE, Nicolas, STOJAN, Jure, COLLETIER, Jacques-Philippe, GOBEC, Stanislav. Structure-based drug design : from selective butyrylcholinesterase towards multifunctional anti-Alzheimer ligands. In: ANDERLUH, Gregor (ed.), PODOBNIK, Marjetka (ed.). Advances in structural biology : mini simpozij 2017 : [26th October 2017, Ljubljana]. Ljubljana: Department of Molecular Biology and Nanobiotechnology D11, National Institute of Chemistry, 2017. Str. 16, ilustr. ISBN 978-961-6104-37-1. [COBISS.SI-ID 4439921]

10. KNEZ, Damijan, COQUELLE, Nicolas, PIŠLAR, Anja, ŽAKELJ, Simon, JUKIČ, Marko, SOVA, Matej, MRAVLJAK, Janez, NACHON, Florian, BRAZZOLOTTO, Xavier, KOS, Janko, COLLETIER, Jacques-Philippe, GOBEC, Stanislav. Butyrylcholinesterase inhibitors grafted with antioxidant and neuroprotective activities : novel multifunctional ligands for Alzheimer's disease. In: 13th International Meeting on Cholinesterases and the 7th International Conference on Paraoxonases, Hradec Králové, Czech Republic 9 th - 14th September 2018. Hradec Králové: Univerzita obrany, Fakulta vojenského zdravotnictví, 2018. Str. 127. Military Medical Science Letters, Vol. 87, iss. 2, 2018. ISSN 2571-113X. https://www.mmsl.cz/artkey/mms-201802-0008_13th-international-meeting-on-cholinesterases-7th-international-conference-on-paraoxonases.php, http://system.bpp.cz/upload/files/Chepon2018/MMSL_2018_RGB_supplementum_1.pdf. [COBISS.SI-ID 4594289]

11. BRUS, Boris, KOŠAK, Urban, KNEZ, Damijan, COQUELLE, Nicolas, COLLETIER, Jacques-Philippe, GOBEC, Stanislav. Disubstituted piperidine derivatives as butyrylcholinesterase inhibitors for use in the treatment of Alzheimer : European patent specification EP 3256128 (B1), 2018-11-14. München: European Patent and Trademark Office, 2018. 47 str., ilustr. https://register.epo.org/application?number=EP16720556. [COBISS.SI-ID 4224113]
patent family: EP3256128 (A1), 2017-12-20; P201500076, 2015-03-25; US10071964 (B2), 2018-09-11; SI24951 (A), 2016-09-30; WO2016151484 (A1) , 2016-09-29

12. KOŠAK, Urban, BRUS, Boris, KNEZ, Damijan, ŽAKELJ, Simon, TRONTELJ, Jurij, PIŠLAR, Anja, ŠINK, Roman, JUKIČ, Marko, ŽIVIN, Marko, PODKOWA, Adrian, NACHON, Florian, BRAZZOLOTTO, Xavier, STOJAN, Jure, KOS, Janko, COQUELLE, Nicolas, SAŁAT, Kinga, COLLETIER, Jacques-Philippe, GOBEC, Stanislav. The magic of crystal structure-based Inhibitor optimization : development of a butyrylcholinesterase inhibitor with picomolar affinity and In vivo activity. Journal of medicinal chemistry. 2018, vol. 61, iss. 1, str. 119-139, ilustr. ISSN 0022-2623. http://pubs.acs.org/doi/10.1021/acs.jmedchem.7b01086, DOI: 10.1021/acs.jmedchem.7b01086. [COBISS.SI-ID 4444017]

13. KNEZ, Damijan, COQUELLE, Nicolas, PIŠLAR, Anja, ŽAKELJ, Simon, JUKIČ, Marko, SOVA, Matej, MRAVLJAK, Janez, NACHON, Florian, BRAZZOLOTTO, Xavier, KOS, Janko, COLLETIER, Jacques-Philippe, GOBEC, Stanislav. Multi-target-directed ligands for treating Alzheimer's disease : butyrylcholinesterase inhibitors displaying antioxidant and neuroprotective activities. European journal of medicinal chemistry. [Print ed.]. Aug. 2018, vol. 156, str. 598-617, ilustr. ISSN 0223-5234. https://www.sciencedirect.com/science/article/pii/S0223523418305890, DOI: 10.1016/j.ejmech.2018.07.033. [COBISS.SI-ID 4547697]

14. PAJK, Stane, KNEZ, Damijan, KOŠAK, Urban, ZOROVIĆ, Maja, BRAZZOLOTTO, Xavier, COQUELLE, Nicolas, NACHON, Florian, COLLETIER, Jacques-Philippe, ŽIVIN, Marko, STOJAN, Jure, GOBEC, Stanislav. Development of potent reversible selective inhibitors of butyrylcholinesterase as fluorescent probes. Journal of enzyme inhibition and medicinal chemistry. 2020, vol. 35, iss. 1, str. 498-505, ilustr., graf. prikazi. ISSN 1475-6366. https://www.tandfonline.com/doi/full/10.1080/14756366.2019.1710502, Repository of the University of Ljubljana – RUL , DOI: 10.1080/14756366.2019.1710502. [COBISS.SI-ID 4869233]