Samo Guzelj

1. GUZELJ, Samo. Načrtovanje in sinteza zaviralcev ksantinske oksidaze s piridil-1,2,4-oksadiazolnim ogrodjem = Design and synthesis of xanthine oxidase inhibitors based on a pyridil-1,2,4-oxadiazole scaffold : magistrska naloga ; enovit magistrski študij farmacija. Ljubljana: [S. Guzelj], 2017. VII, 62 f., ilustr., tabele. http://www.ffa.uni-lj.si/docs/default-source/knjiznica-doc/magistrske/2017/guzelj_samo_mag_nal_2017.pdf?sfvrsn=2, Repozitorij Univerze v Ljubljani – RUL. [COBISS.SI-ID 4424305]

2. GUZELJ, Samo. Conjugated pattern recognition receptor agonists as vaccine adjuvants and immunotherapeutics : vabljeno predavanje na spletnem dogodka Uni.Minds, 10 november 2020. https://whova.com/web/uktof_202010/Speakers. [COBISS.SI-ID 66860547]

3. GUZELJ, Samo, GOBEC, Martina, URBANČIČ, Dunja, MLINARIČ-RAŠČAN, Irena, CORSINI, Emanuela, JAKOPIN, Žiga. Structural features and functional activities of benzimidazoles as NOD2 antagonists. European journal of medicinal chemistry. [Print ed.]. Mar. 2020, vol. 190, str. 1-15, ilustr. ISSN 0223-5234. https://www.sciencedirect.com/science/article/pii/S0223523420300568?via%3Dihub, https://www.sciencedirect.com/science/article/pii/S0223523420300568?via%3Dihub#appsec1, DOI: 10.1016/j.ejmech.2020.112089. [COBISS.SI-ID 4874097]
project: P1-0208; funder: ARRS
project: STSM-CA15135-090117-082301; funder: COST action CA15135 “Multi-target para- digm for innovative ligand identification in the drug discovery proces

4. GUZELJ, Samo, JAKOPIN, Žiga. Synthesis of conformationally constrained d-Glu-meso-DAP analogs as innate immune agonists. Molecules. 2020, vol. 25, no. 22, str. 1-13, ilustr. ISSN 1420-3049. https://www.mdpi.com/1420-3049/25/22/5228, Repozitorij Univerze v Ljubljani – RUL, DOI: 10.3390/molecules25225228. [COBISS.SI-ID 36482307]

5. HASSAN, Mujtaba, BAUSSIÈRE, Floriane, GUZELJ, Samo, SUNDIN, Anders, HÅKANSSON, Maria, WALSE, Björn, DIEHL, Carl, TOMAŠIČ, Tihomir, ANDERLUH, Marko, JAKOPIN, Žiga, et al. Design, synthesis and evaluation of d-galactal derivatives as selective inhibitors of galectin-8 n-terminal domain. In: Book of abstracts. 2021. Str. 155, a008. https://www.efmc-ismc.org/v2/data/1630081893EFMC-ISMC-BookOfAbstracts-webHD.pdf. [COBISS.SI-ID 74924291]

6. FRKANEC, Ruža, ŠTIMAC, Anton, JAKOPIN, Žiga, GUZELJ, Samo, GAZDEK, N., FRKANEC, Leo. Mixed adjuvant formulation based on peptide hydrogel and desmuramyl peptides: preparation and influence on specific immune reaction : 45th FEBS Congress, Molecules of Life: Towards New Horizons, Ljubljana, Slovenia, July 3-8, 2021. FEBS open bio. 2021, vol. 11, issue s1, str. 296. ISSN 2211-5463. https://febs.onlinelibrary.wiley.com/doi/10.1002/2211-5463.13205, DOI: 10.1002/2211-5463.13205. [COBISS.SI-ID 69801475]

7. GUZELJ, Samo, NABERGOJ, Sanja, GOBEC, Martina, PAJK, Stane, KLANČIČ, Veronika, SLÜTTER, Bram, FRKANEC, Ruža, ŠTIMAC, Adela, ŠKET, Primož, PLAVEC, Janez, MLINARIČ-RAŠČAN, Irena, JAKOPIN, Žiga. Structural fine-tuning of desmuramylpeptide NOD2 agonists defines their in vivo adjuvant activity. Journal of medicinal chemistry. 2021, vol. 64, iss. 11, str. 7809-7838, ilustr. ISSN 0022-2623. https://pubs.acs.org/doi/10.1021/acs.jmedchem.1c00644, Repozitorij Univerze v Ljubljani – RUL, DOI: 10.1021/acs.jmedchem.1c00644. [COBISS.SI-ID 64930051]
project: P1-0208; funder: ARRS
project: J3-9256; funder: ARRS
project: IP-2018-01-6910; funder: Croatian Science Foundation
project: STSM-CA16231- 130120-114265; funder: COST action CA16231 “European Network of Vaccine Adjuvants (ENOVA)”

8. GUZELJ, Samo, NABERGOJ, Sanja, GOBEC, Martina, PAJK, Stane, KLANČIČ, Veronika, SLÜTTER, Bram, FRKANEC, Ruža, ŠTIMAC, Adela, ŠKET, Primož, PLAVEC, Janez, MLINARIČ-RAŠČAN, Irena, JAKOPIN, Žiga. Structural fine-tuning of desmuramylpeptide NOD2 agonists defines their in vivo adjuvant activity. In: Book of abstracts. 2021. Str. 431, z028. https://www.efmc-ismc.org/v2/data/1630081893EFMC-ISMC-BookOfAbstracts-webHD.pdf. [COBISS.SI-ID 74952707]

9. GUZELJ, Samo, NABERGOJ, Sanja, GOBEC, Martina, PAJK, Stane, KLANČIČ, Veronika, SLÜTTER, Bram, FRKANEC, Ruža, ŠTIMAC, Adela, ŠKET, Primož, PLAVEC, Janez, MLINARIČ-RAŠČAN, Irena, JAKOPIN, Žiga. Structural fine-tuning of desmuramylpeptide NOD2 agonists defines their in vivo adjuvant activity. In: Book of abstracts. 2021. Str. 106, po42, ilustr. https://www.efmc-ymcs.org/v2/data/1630930688BookYMCS-Virtual-HD.pdf. [COBISS.SI-ID 76062467]

10. HASSAN, Mujtaba, BAUSSIÈRE, Floriane, GUZELJ, Samo, SUNDIN, Anders, HÅKANSSON, Maria, KOVAČIČ, Rebeka, LEFFLER, Hakon, TOMAŠIČ, Tihomir, ANDERLUH, Marko, JAKOPIN, Žiga, et al. Structure-guided design of D-galactal derivatives with high affinity and selectivity for the galectin-8 n-terminal domain. ACS Medicinal Chemistry Letters. 2021, vol. 12, iss. 11, str. 1745-1752, ilustr. ISSN 1948-5875. https://pubs.acs.org/doi/full/10.1021/acsmedchemlett.1c00371, Repozitorij Univerze v Ljubljani – RUL, DOI: 10.1021/acsmedchemlett.1c00371. [COBISS.SI-ID 83202819]
project: 765581; funder: Union's Horizon 2020 research and innovation program under the Marie Skłodowska-Curie Grant Agreement

11. JAKOPIN, Žiga, GUZELJ, Samo. Conjugated TLR7 and NOD2 agonists : WO2022084417A1·2022-04-28. [Geneva]: World Intellectual Property Organization, 2022. 92 str., ilustr. https://worldwide.espacenet.com/patent/search/family/074175904/publication/WO2022084417A1?q=PCT%2FEP2021%2F079141. [COBISS.SI-ID 108878595]

12. GUZELJ, Samo, WEISS, Matjaž, SLÜTTER, Bram, FRKANEC, Ruža, JAKOPIN, Žiga. Covalently conjugated NOD2/TLR7 agonists are potent and versatile immune potentiators. Journal of medicinal chemistry. [Online ed.]. 2022, vol. 65, no. 22, str. 15085–15101, ilustr. ISSN 1520-4804. https://pubs.acs.org/doi/full/10.1021/acs.jmedchem.2c00808#, Repozitorij Univerze v Ljubljani – RUL, DOI: 10.1021/acs.jmedchem.2c00808. [COBISS.SI-ID 128189187]
project: P1-0208; funder: ARRS
project: P1-0420; funder: ARRS
project: J3-9256; funder: ARRS
project: IP-2018-01-6910; funder: Croatian Science Foundation
project: STSM-CA16231-130120-114265; funder: COST action CA16231 “European Network of Vaccine Adjuvants (ENOVA)”

13. GUZELJ, Samo. Development of novel NOD2 agonists and dual NOD2 and TLR7 agonists as vaccine adjuvants = Razvoj novih agonistov NOD2 in dvojnih agonistov NOD2 in TLR7 kot novih adjuvansov za cepiva : doctoral dissertation. Ljubljana: [S. Guzelj], 2022. 392 str., ilustr., graf. prikazi. Repozitorij Univerze v Ljubljani – RUL, Digitalna knjižnica Slovenije - dLib.si. [COBISS.SI-ID 120062211]
project: P1-0208 Farmacevtska kemija: načrtovanje, sinteza in vrednotenje učinkovin; funder: ARRS
project: P1-0420 Napredna imunološka zdravila in celični pristopi v farmaciji; funder: ARRS
project: J3-9256 Razvoj agonistov receptorja NOD2 ter dualnih NOD2/TLR7 agonističnih konjugatov kot novih adjuvansov za cepiva; funder: ARRS
project: IP-2018-01-6910; funder: Croatian Science Foundation
project: STSM-CA16231-130120-114265 European Network of Vaccine Adjuvants (ENOVA); funder: COST action CA16231
project: Multi-target paradigm for innovative ligand identifictiopn in drug discovery process (MuTaLig); funder: COST actions CA15135

14. GUZELJ, Samo, JANEŽ, Špela, JAKOPIN, Žiga. Discovery of desmuramylpeptide NOD2 agonists with single-digit nanomolar potency. ACS Medicinal Chemistry Letters. 2022, vol. 13, iss. 8, str. 1270-1277, ilustr. ISSN 1948-5875. https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.2c00121, Repozitorij Univerze v Ljubljani – RUL, DOI: 10.1021/acsmedchemlett.2c00121. [COBISS.SI-ID 117643267]
project: P1−0208; funder: ARRS
project: P1−0420; funder: ARRS
project: J3−9256; funder: ARRS

15. JANEŽ, Špela. Farmakokinetična in farmakodinamična optimizacija dezmuramilpeptidnih agonistov receptorja prirojene imunosti NOD2 = Pharmacokinetic and pharmacodynamic optimisation of desmuramylpeptide agonists of innate immune receptor NOD2. In: PLEVNIK, Miha (ed.), et al. 52. Krkine nagrade = 52nd Krka Prizes : zbornik povzetkov = book of abstracts : 32. simpozij = 32nd symposium : [Novo mesto, 21. oktober 2022]. Novo mesto: Krka, [2022]. Str. 77. [COBISS.SI-ID 126963715]

16. JANEŽ, Špela. Farmakokinetična in farmakodinamična optimizacija dezmuramilpeptidnih agonistov receptorja prirojene imunosti NOD2 = Pharmacokinetic and pharmacodynamic optimization of desmuramylpeptide agonists of the innate immune receptor NOD2 : [delo za Prešernovo nagrado]. Ljubljana: [Š. Bizjak], 2022. VI, 78 f., ilustr., tabele. [COBISS.SI-ID 174542339]

17. JANEŽ, Špela. Farmakokinetična in farmakodinamična optimizacija dezmuramilpeptidnih agonistov receptorja prirojene imunosti NOD2 = Pharmacokinetic and pharmacodynamic optimization of desmuramylpeptide agonists of the innate immune receptor NOD2 : enoviti magistrski študij farmacija. Ljubljana: [Š. Bizjak], 2022. X, 77 str., ilustr. [COBISS.SI-ID 111577603]

18. GUZELJ, Samo, ŠIŠIĆ, Marcela, JANEŽ, Špela, FRKANEC, Leo, FRKANEC, Ruža, JAKOPIN, Žiga. Lipidation of NOD2 agonists with adamantane and stearoyl moieties differentially regulates their In vivo adjuvant activity. Pharmaceutics. [Online ed.]. 2022, vol. 14, iss. 12, art. 2755, 9 str., ilustr. ISSN 1999-4923. https://www.mdpi.com/1999-4923/14/12/2755, Repozitorij Univerze v Ljubljani – RUL, DOI: 10.3390/pharmaceutics14122755. [COBISS.SI-ID 133033219]
project: P1-0208; funder: ARRS
project: P1-0420; funder: ARRS
project: J3-2517; funder: ARRS
project: J3-9256; funder: ARRS
project: IP-2018-01-6910; funder: Croatian Science Foundation

19. GUZELJ, Samo, TOMAŠIČ, Tihomir (author, corresponding author), JAKOPIN, Žiga. Novel scaffolds for modulation of NOD2 identified by pharmacophore-based virtual screening. Biomolecules. 2022, vol. 12, iss. 8, art. 1054, 17 str., ilustr. ISSN 2218-273X. https://www.mdpi.com/2218-273X/12/8/1054, Repozitorij Univerze v Ljubljani – RUL, DOI: 10.3390/biom12081054. [COBISS.SI-ID 117616387]
project: P1-0208; funder: ARRS
project: P1-0420; funder: ARRS
project: J3-9256; funder: ARRS

20. GUZELJ, Samo, JAKOPIN, Žiga. Nucleotide-Binding oligomerization domain 1/Toll-like receptor 4 co-engagement promotes non-specific immune response against K562 cancer cells. Frontiers in pharmacology. 2022, vol. 13, art. 920928, 12 str., ilustr. ISSN 1663-9812. https://www.frontiersin.org/articles/10.3389/fphar.2022.920928/full, Repozitorij Univerze v Ljubljani – RUL, DOI: 10.3389/fphar.2022.920928. [COBISS.SI-ID 117623555]
project: P1-0208; funder: ARRS
project: P1-0420; funder: ARRS
project: J3-2517; funder: ARRS

21. GUZELJ, Samo. Razvoj novih agonistov NOD2 in dvojnih agonistov NOD2 in TLR7 kot novih adjuvansov za cepiva = Development of novel NOD2 Agonists and dual NOD2 and TLR7 agonists as vaccine adjuvants. In: PLEVNIK, Miha (ed.), OBERSTAR FALKNER, Maja, GORJUP, Simona. 53. Krkine nagrade = 53nd Krka Prizes : zbornik povzetkov = book of abstracts : 33. simpozij = 33rd symposium : [Novo mesto, 20. oktober 2023]. Novo mesto: Krka, [2023]. Str. 48. [COBISS.SI-ID 171839235]

22. PARADISO, Emiliano, JANEŽ, Špela, GUZELJ, Samo, JAKOPIN, Žiga. Development of chimeric innate immune agonists as vaccine adjuvants. In: KRAJNC, Alen (ed.), GOBEC, Martina (ed.). Brunching with soft- and research skills at UL FFA: unlocking your full potential : 1st UL FFA Graduate Student Research Symposium : book of abstracts : University of Ljubljana, Faculty of Pharmacy, April 2024. Online ed. Ljubljana: Faculty of Pharmacy, 2024. Str. 36, ilustr. ISBN 978-961-6378-97-0. https://www.ffa.uni-lj.si/docs/default-source/e-knjige/brunching-with-soft-and-research-skills-at-ul-ffa.pdf?sfvrsn=2. [COBISS.SI-ID 198157059]

23. RUSSO, Camilla, RUSSOMANNO, Pasquale, D’AMORE, Vincenzo Maria, ALFANO, Antonella Ilenia, SANTORO, Federica, GUZELJ, Samo, GOBEC, Martina, AMATO, Jussara, PAGANO, Bruno, JAKOPIN, Žiga, et al. Discovery of 2,3-diaminoindole derivatives as a novel class of NOD antagonists. Journal of medicinal chemistry. [Online ed.]. 2024, vol. 67, iss. 4, str. 3004-3017, ilustr. ISSN 1520-4804. https://pubs.acs.org/doi/10.1021/acs.jmedchem.3c02094, DOI: 10.1021/acs.jmedchem.3c02094. [COBISS.SI-ID 183800579]
project: Financial support from University of Naples Federico II andUniversity of Piemonte Orientale, Novara, is acknowledged.C.R. acknowledges Department of Pharmacy University of Naples Federico II for a PhD fellowship. This research was alsofunded by the Slovenian Research Agency (Grants No. P1-0420, J3-2517, and J3-4496).

24. JANEŽ, Špela, GUZELJ, Samo, KOCBEK, Petra, DE VLIEGER, Eveline A., SLÜTTER, Bram, JAKOPIN, Žiga. Distinctive immune signatures driven by structural alterations in desmuramylpeptide NOD2 agonists. Journal of medicinal chemistry. [Online ed.]. 2024, vol. 67, iss. 19, str. 17585-17607, ilustr. ISSN 1520-4804. https://pubs.acs.org/doi/10.1021/acs.jmedchem.4c01577, Repozitorij Univerze v Ljubljani – RUL, DOI: 10.1021/acs.jmedchem.4c01577. [COBISS.SI-ID 209432835]
project: This research was funded by the Slovenian Research Agency (Grants P1-0420, J3-2517, J3-4496 and Young Researcher’s programme, 56838 (Š.J.)).

25. JANEŽ, Špela, GUZELJ, Samo, JAKOPIN, Žiga. Linker chemistry and connectivity fine-tune the immune response and kinetic solubility of conjugated NOD2/TLR7 agonists. Bioconjugate chemistry. [Online ed.]. 2024, vol. 35, iss. 11, str. 1723-1731, ilustr. ISSN 1520-4812. https://pubs.acs.org/doi/10.1021/acs.bioconjchem.4c00321, https://pubs.acs.org/doi/epdf/10.1021/acs.bioconjchem.4c00321?ref=article_openPDF, Repozitorij Univerze v Ljubljani – RUL, DOI: 10.1021/acs.bioconjchem.4c00321. [COBISS.SI-ID 211169539]
project: This research was funded by the Slovenian Research Agency(Grants P1-0420, J3-2517, J3-4496, and Young Researcher’sprogram, 56838.

26. PELETTǍ, Allegra, MARMY, Aurélie, GUZELJ, Samo, RAMOS BARROS, Alcidia, JAKOPIN, Žiga, BORCHARD, Gerrit. Preliminary results on novel adjuvant combinations suggest enhanced immunogenicity of whole inactivated pandemic influenza vaccines. Frontiers in drug delivery. 2024, vol. 4, 14 str., ilustr., graf. prikazi. ISSN 2674-0850. https://www.frontiersin.org/journals/drug-delivery/articles/10.3389/fddev.2024.1382266/full, Repozitorij Univerze v Ljubljani – RUL, DOI: 10.3389/fddev.2024.1382266. [COBISS.SI-ID 209452291]
project: The research was founded by Swiss National founding, grant no: IZCOZ0_182947.